The arguments for and against cannabinoids application in glaucomatous retinopathy.

نویسندگان

  • Yunes Panahi
  • Azadeh Manayi
  • Marjan Nikan
  • Mahdi Vazirian
چکیده

Glaucoma represents several optic neuropathies leading to irreversible blindness through progressive retinal ganglion cell (RGC) loss. Reduction of intraocular pressure (IOP) is known as the only modifiable factor in the treatment of this disorder. Application of exogenous cannabinoids to lower IOP has attracted attention of scientists as potential agents for the treatment of glaucoma. Accordingly, neuroprotective effect of these agents has been recently described through modulation of endocannabinoid system in the eye. In the present work, pertinent information regarding ocular endocannabinoid system, mechanism of exogenous cannabinoids interaction with the ocular endocannabinoid system to reduce IOP, and neuroprotection property of cannabinoids will be discussed according to current scientific literature. In addition to experimental studies, bioavailability of cannabinoids, clinical surveys, and adverse effects of application of cannabinoids in glaucoma will be reviewed.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Protection of neurons in the retinal ganglion cell layer against excitotoxicity by the N-acylethanolamine, N-linoleoylethanolamine

Retinal ganglion cell (RGC) death is a hallmark of neurodegenerative diseases and disease processes of the eye, including glaucoma. The protection of RGCs has been an important strategy for combating glaucoma, but little clinical success has been reported to date. One pathophysiological consequence of glaucoma is excessive extracellular glutamate subsequently leading to excitotoxicity in the re...

متن کامل

Therapeutic potential of Juglans regia L. leaf extract against diabetic retinopathy in rat

Objective(s): Oxidative stress has a pivotal role in the pathogenesis of diabetic retinopathy (DR). Juglans regia L. (JRL) leaf extract has hypoglycemic and antioxidative properties. This study aimed to determine the ameliorative effects of JRL against diabetic retinopathy. Materials and Methods: The DR rat model was generated by injection of streptozotocin (STZ). A subset of the diabetic rats ...

متن کامل

Prediction of Preventive Behaviors of Retinopathy in Type 2 Diabetic Patients: An Application of the Theory of Planned Behavior

Introduction: Primary eye care is the most important element in the prevention of retinopathy. The present study aimed to assess the prevention of retinopathy in type 2 diabetic patients, based on the theory of planned behavior. Materials and Methods: This descriptive analytical study of need assessment was carried out on 94 random patients with type 2 diabetes, who were referred to a diabetes ...

متن کامل

Emerging Psychedelics: A Systematic Review of Synthetic Cannabinoids

Objective: In recent years, the advent of synthetic cannabinoids, deceptive advertising and cyber sales has led young people to use them. The United Nations Office on Drugs and Crime (UNODC) has identified the prevalence of using these compounds as a major public health challenge. The aim of the present study was to systematically review synthetic cannabinoids. Method: This study was a descript...

متن کامل

Acetylcholinesterase Inhibitory Activity of Standardized Cannabinoids-rich Fractions

Background: Since cannabis has been legally allowed for medicinal purposes in many countries, it has become more interesting issue, particularly in neurologic disorders such as Alzheimer’s disease (AD). Inhibition of acetylcholinesterase (AChE) is one of the mechanisms for the treatment of AD. Objectives: The present study aimed to establish a method for preparation of cannabinoids-rich extrac...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

دوره 86  شماره 

صفحات  -

تاریخ انتشار 2017